With the rapid development of precision medicine and immunotherapy, vaccine research and development is gradually moving from the traditional "broad-spectrum protection" model to a precise design era centered on individual immune characteristics. Especially in the fields of cancer vaccines and vaccines for complex diseases, how to efficiently identify key antigens, accurately predict immune responses, and translate them into viable vaccine candidates has become a core issue of common concern in the industry.
During the early research stage of vaccines, the precise identification of antigens and epitopes is the key to determining the success rate of subsequent research and development. The next-generation sequencing (NGS) services provided by Creative Biolabs can conduct high-throughput analysis of tumor samples or pathogen-related sequences, helping researchers comprehensively analyze the mutation spectrum, immune-related gene characteristics, and potential sources of neoantigens, laying a data foundation for subsequent vaccine design.
Based on this, Creative Biolabs further introduced the peptide microarray technology to achieve high-throughput functional validation of candidate antigenic epitopes. This technology can simultaneously detect the interactions between hundreds to thousands of peptides and antibodies or immune cells in the same experiment, significantly improving the efficiency and accuracy of epitope screening and reducing the high trial-and-error costs associated with traditional approaches.
"Relying solely on bioinformatics prediction is no longer sufficient to meet the demands of the next-generation vaccine development; high-throughput validation at the experimental level is equally indispensable," said an immunology expert at Creative Biolabs. "By integrating NGS data with peptide microarray technology, we can more confidently identify the key epitopes that truly have immunological significance."
After the candidate epitopes are identified, Creative Biolabs' personalized neoantigen mRNA cancer vaccine platform can quickly transform research results into developable vaccine construction plans. This platform supports an integrated service from neoantigen design and mRNA sequence optimization to in vitro functional validation, helping customers shorten the cycle from proof of concept to preclinical research.
The expert further pointed out, "mRNA technology provides a highly flexible delivery modality for personalized vaccines, while the real challenge lies in the scientificity and reliability of the front-end antigen screening. We hope to help our clients reduce uncertainties in the complex R&D path through end-to-end technology integration."
By integrating data analysis, epitope validation, and vaccine construction capabilities, Creative Biolabs is building a vaccine research and development support system that is more in line with the current trend of precision immunology, providing a solid technical foundation for tumor vaccines and other innovative vaccine projects. In the future, the company will also continue to expand related technology platforms to help more innovative vaccines accelerate their progress to clinical trials and applications.
Media Contact
Company Name: Creative Biolabs
Contact Person: Candy Swift
Email: Send Email
State: New York
Country: United States
Website: https://www.creative-biolabs.com/vaccine/